Oral composition

ABSTRACT

Disclosed is an oral composition comprising palatinit. More particularly, disclosed is an oral composition comprising palatinit which exerts a synergistic effect when combined with a fluorine or zinc compound.

TECHNICAL FIELD

[0001] The present invention relates to an oral composition comprisingpalatinit, and more particularly, it relates to an oral compositioncomprising palatinit which exhibits the synergistic effect when combinedwith a fluorine or zinc compound.

BACKGROUND ART

[0002] Dental caries is a state of a dental carious cavity caused by thedissolution of calcium from teeth and which can not naturally return toa healthy state. But, there is a state referred to as a sub-surfacelesion which can return to the healthy state, in the course of thedevelopment of the dental carious cavity (“Zusetsu Ushoku-gaku” editedby Shoichi, Suga, 1990, 139). Therefore, in order to decrease dentalcaries, it is desirable to enhance the remineralization so that theteeth can return to the healthy state within a term during which theteeth return to the original state.

[0003] As a method for enhancing the remineralization, the use offluorine compounds has been known for a long time. However, because theingestion of a large amount of fluorine exhibits the toxicity, it isdesired that fluorine be effectively utilized in an as smaller aspossible amount. To accomplish this, the use of a substance thatenhances the remineralization effect of fluorine is exemplified. Forexample, there is proposed a combination of fluorine and hydroxy-apatitein JP-A-1-110608. However, its effect is insufficient and is notsatisfactory.

[0004] On the other hand, a zinc compound that has been utilized in theoral composition generally has an astringent or salty taste and,therefore, there is a problem that it has the very bad feeling for useupon its use.

[0005] One object of the present invention is to provide an oralcomposition which has the high safety and can enhance theremineralization. Another object of the present invention is to providean oral composition which exhibits the sufficient remineralizationeffect and has the better feeling for use.

DISCLOSURE OF INVENTION

[0006] In view of the above circumstances, the present inventors studiedintensively the substances that can enhance the remineralization and, asa result, found that palatinit exhibits the excellent properties, thatan oral composition comprising palatinit can enhance theremineralization, and, further, that the inclusion of palatinit in acombination with a fluorine or zinc compound can enhance theremineralization due to the synergistic effect of both ingredients,which resulted in the completion of the present invention.

[0007] Palatinit has hitherto been utilized in foods and the like as alow cariogenic sweetener. However, palatinit has never been utilized foran oral-use, and its remineralization effect is not known.

[0008] That is, the present invention has completed based on such novelfindings, and, in the first aspect, provides an oral compositioncomprising palatinit which has the high safety and can enhance theremineralization.

[0009] Moreover, in the second aspect, the present invention provides anoral composition comprising palatinit and a remineralization enhancingingredient, which s a exhibits the sufficient remineralization effectand has the better feeling for use.

[0010] The present invention is described below in detail according tothe first and second aspects thereof in sequence.

[0011] [First Aspect]

[0012] Palatinit to be used in the first and second aspects of thepresent invention is a sugar alcohol of a disaccharide, and may beα-D-glucopyranosyl-1,6-mannitol, its isomer,α-D-glucopyranosyl-1,6-sorbitol or a mixture thereof Palatinit can beobtained by hydrogenation of palatinose which is converted from sucroseas a raw material with glycosyltransferase. And, palatinit is also atrade name of the product of Mitsui Sugar Co. Ltd. or Sudzucker A. G.,and is also referred to as reduced-palatinose or isomalt. Palatinit iswidely known as a non-cariogenic sugar which scarcely develops dentalcaries, based on the fact that the cariogenic microorganisms do notproduce acids from palatinit in an oral cavity. Palatinit has beenblended in non-sugar foods or a specified health food such as so-called“dental caries-resistant candy”.

[0013] The amount of palatinit to be blended in the present oralcomposition is in the range of 0.1% to 60% by weight, preferably 1% to40% by weight, based on the total weight of the oral composition. Whenthe amount is less than 0.1% by weight, the desired effect can not beobtained. On the other hand, when the amount is more than 60% by weight,the stability of the formulation is deteriorated.

[0014] [Second Aspect]

[0015] The remineralization enhancing ingredient to be used in thesecond aspect of the present invention is an ingredient which canremineralize the teeth from its sub-surface lesion state. Examples ofthe remineralization enhancing ingredient are fluorine compounds, zinccompounds, phosphorus compounds, calcium compounds and the like, but notlimited thereto.

[0016] Examples of the fluorine compound to be used in the second aspectof the present invention as the remineralization enhancing ingredientare sodium fluoride, potassium fluoride, ammonium fluoride, stannousfluoride, sodium or potassium monofluorophosphate and the like.Particularly preferred are sodium fluoride and sodiummonofluorophosphate.

[0017] These fluorine compounds, alone or in a combination thereof, maybe blended in the present oral composition in the range of 0.1-5,000ppm, preferably 100-1,100 ppm in terms of fluoride ion, based on thetotal weight of the present oral composition.

[0018] Further, the zinc compound to be used in the second aspect of thepresent invention as the remineralization enhancing ingredient ispreferably a water-slightly soluble zinc compound, wherein thewater-slightly soluble zinc compound is defined as having the solubilityof less than 0.5 g per 100 g of water at 25° C., and water-insolublezinc compound is included therein. Among them, particularly preferredare zinc oxide, zinc citrate and zinc stearate. From a viewpoint of ataste, the water-slightly soluble zinc compound having a smallerparticle diameter and a greater specific surface area is preferred. Moreparticularly, preferred are those having the particle diameter of notgreater than 0.3 μm and the specific surface area of greater than 10m²/g. When the particle diameter exceeds 0.3 μm, the astringency becomesstrong. Examples of the commercial products of the zinc compound arefine particle zinc white and hyperfine particle zinc oxide, “FINEXseries” manufactured by Sakai Chemical Industry Co., Ltd. Thesewater-slightly soluble zinc compounds, alone or in a combinationthereof, may be blended in the oral composition in the amount of 0.1% to5% by weight, based on the total weight of the present oral composition.

[0019] Further, when the oral composition of the second aspect of thepresent invention contains a zinc compound, preferred pH thereof iswithin the range of 6.0 to 8.5. When pH is lower than 6.0, then theastringency is strong, and when pH is higher than 8.5, then oral mucosamay be irritated, therefore, the composition out of the above pH rangeis not preferable.

[0020] Further, examples of the phosphorus compound to be used in thesecond aspect of the present invention as the remineralization enhancingingredient are disodium hydrogenphosphate, sodium dihydrogenphosphate,dipotassium hydrogenphosphate, potassium dihydrogenphosphate, trisodiumphosphate, tripotassium phosphate and the like, but not limited thereto.

[0021] Moreover, examples of the calcium compound to be used in thesecond aspect of the present invention as the remineralization enhancingingredient are, for example, calcium chloride, calcium nitrate, calciumsulfate, calcium carbonate, calcium citrate, calciumhydrogenpyrophosphate, calcium gluconate, calcium glycerophosphate,calcium hydroxide, calcium oxide, calcium silicate and the like, but notlimited thereto.

[0022] That is, the present invention provides an oral compositioncomprising palatinit alone or in a combination with any remineralizationenhancing ingredients, which can enhance the remineralization due to thesynergistic effect of both ingredients.

[0023] The oral composition of the present invention may be properlyformulated, depending upon its use, into a form such as a toothpaste,powder or liquid dentifrice, wetting dentifrice, gel, cream, pasta,mouthwash, spray, foam, coating agent and the like, according to theconventional procedure. Other ingredients to be blended therein are notparticularly limited, and the known active ingredients, polishingagents, humectants, thickening agents, foaming agents, preservatives,flavoring agents, sweeteners, pH adjusting agents, organic acids, sugaralcohol, anti-oxidizing agents and others known as the ingredient forthe oral composition may be blended in the oral composition, so long asthey do not deteriorate the effects of the present invention.

[0024] Examples of the active ingredient are enzymes such as amylase,protease, lysozyme and dextranase, the antimicrobial agents such assanguinarine, allantoin, aminobenzoate derivatives, hexetidine,chlorhexidine, triclosan and cetylpyridinium chloride, vitamins such asvitamin B, C and E, and the astringents such as potassium nitrate,lithium nitrate and sodium nitrate.

[0025] Examples of the polishing agent are silica, alumina,aluminosilicate, aluminium hydroxide and the like.

[0026] Examples of the humectant are glycerol, propylene glycol,sorbitol, polyethylene glycol, polypropylene glycol and the like.

[0027] Examples of the thickening agent are sodium carboxymethylcellulose, methyl cellulose, hydroxyethyl cellulose, alginates, xanthangum, carrageenan, gum arabic, polyvinyl alcohol and the like.

[0028] Examples of the forming agent are anionic-, nonionic-, cationic-and amphoteric-surfactants. Examples of the anionic-surfactant are alkylsulfates, sodium dodecylbenzene sulfonate, amino acids, sulfosuccinates,sucrose fatty acid esters and the like. Examples of thenonionic-surfactant are Pluronic series that arepolyoxyethylene-polyoxypropylene copolymer, fatty acid dialkanolamidesand the like.

[0029] Examples of the preservative are methylparaben, propylparaben,benzoates, sodium benzoate, paraoxybenzoic acid esters, titanium dioxideand the like.

[0030] Examples of the flavoring agent are peppermint oil, spearmintoil, Japanese peppermint oil, orange oil, menthol, cloves oil, aniseoil, wintergreen oil, eucalyptus oil and the like.

[0031] Examples of the sweetening agent or sweetener are saccharinsalts, dextrose, Aspartame, xylitol, stevia extract, Acesulfame,granulated sugar, powdered sugar, starch syrup and the like. Althoughpalatinit exhibits sweetness, the above sweetening agents or sweetenersmay be added depending upon the feeling for use of the formulation.

[0032] Examples of the pH adjusting agent are citric acid and saltsthereof, phosphoric acid and salts thereof, malic acid and saltsthereof, gluconic acid and salts thereof, maleic acid and salts thereof,aspartic acid and salts thereof, gluconic acid and salts thereof,succinic acid and salts thereof, glucuronic acid and salts thereof,fumaric acid and salts thereof, glutamic acid and salts thereof, adipicacid and salts thereof, lactic acid and salts thereof, pantothenic acidand salts thereof, hydrochloric acid, alkali metal hydroxides and thelike.

BRIEF DESCRIPTION OF DRAWINGS

[0033]FIG. 1 is a graph which compares the remineralization effects ofthe various sugars in the system not containing fluoride.

[0034]FIG. 2 is a graph which compares the remineralization effects ofthe various sugars in the system containing fluoride.

THE BEST MODE FOR CARRYING OUT THE INVENTION

[0035] The present invention will be further illustrated by way of thefollowing Examples, which are not to be construed to limit the scope ofthe present invention. The amounts indicated in the Examples are allpercents (%) by weight.

EXPERIMENTAL EXAMPLE 1

[0036] Evaluation of the Remineralizing Ability 1

[0037] The remineralization effect of the sugars was evaluated in an invitro test using a bovine tooth according to the procedures described inD. J. White et al., Caries Res., 21, 228 (1987).

[0038] 1. An enamel section having 4 mm length×3 mm width was obtainedfrom the bovine tooth. The section was embedded in a dental resin toobtain an enamel block.

[0039] 2. An enamel varnish was applied to a portion of approximately ⅓of the surface of the enamel block in order not to cause thedemineralization of that portion. Then, the enamel block wasdemineralized with a demineralizing solution containing 50% of saturatedhydroxyapatite/0.1M lactic acid/pH 5.0 to prepare an artificial caries.

[0040] 3. An enamel varnish was applied to a portion of approximately ⅔of the surface of the treated enamel block in order not to cause theremineralization of that portion. The enamel block was immersed for tendays in a test solution prepared by adding the test sugar into anaqueous solution containing 3.0 mM calcium ion and 1.8 mM phosphate ionso that the concentration of the sugar became 20%, to perform theremineralization treatment.

[0041] 4. Three thin sections having approximately 500 μm in thicknesswere prepared from the enamel block. The central portion of the thinsections was ground so that the thickness became approximately 100 μmusing a double-side polishing machine.

[0042] 5. The X-ray photograph was taken of the thin section prepared inthe fourth step. The mineral amounts of the demineralized portion andthe remineralized portion were calculated based on the brightness of theeach portion and a distance from the surface using an image processor.The mineral amount difference between the demineralized andremineralized portions was expressed as a remineralization value. Agreater value thereof shows the greater remineralization. A control testwas performed in a similar manner to that described above, except thatthe test solution containing only 3.0 mM calcium ion and 1.8 mMphosphate ion but not containing the sugar was used.

[0043] The results are shown in Table 1 and FIG. 1. TABLE 1 Systems notcontaining fluoride Sugar (20%) Remineralization value Control 405Sorbitol 645 Mannitol 640 Xylitol 416 Erythritol 602 Trehalose 715Palatinit 1057

[0044] Further, a similar test was performed in which sodium fluoridewas added to the test solution to 2 ppm in terms of fluoride ion.

[0045] The results are shown in Table 2 and FIG. 2. TABLE 2 Systemscontaining fluoride (2 ppm) Sugar (20%) Remineralization value Control1626 Sorbitol 1358 Mannitol 1377 Xylitol 1636 Erythritol 1330 Trehalose1205 Palatinit 2374

[0046] From Tables 1 and 2, it was found that, among the sugars tested,palatinit has the particularly excellent remineralizing ability and thatthe remineralizing ability is enhanced by combining palatinit withsodium fluoride.

EXPERIMENTAL EXAMPLE 2

[0047] Evaluation of the Remineralizing Ability 2

[0048] The remineralization enhancing effects of the oral compositionsto which the various sugars had been added were tested in vitroaccording to the similar manner to that described in ExperimentalExample 1.

[0049] Provided that, in the remineralization treatment, a solutioncontaining 3.0 mM calcium ion and 1.8 mM phosphate ion to which a testdentifrice (see Table 3) had been added so as to form a 4-fold slurrywas used, and the immersion period was set to be fourteen days. Theresults of the X-ray photograph were evaluated using the image processoraccording to a similar manner to that described in ExperimentalExample 1. The results are shown in Table 3. TABLE 3 Compara- Compara-Compara- Compara- Compara- tive tive tive tive tive Ingredients Example1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 1 Example 2Example 3 Example 4 Example 5 Silicic acid 20 20 20 20 20 20 20 20 20 2020 anhydride Sodium 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5carboxymethyl cellulose Sorbitol 40 40 35 25 15 15 45 45 35 35 35 Sodiumlauryl 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 sulfate Saccharin 0.10.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 sodium Sodium fluoride — 0.2 0.20.2 0.2 0.2 — 0.2 0.2 0.2 0.2 Flavor 1 1 1 1 1 1 1 1 1 1 1 Xylitol — — —— — — — — 10 — — Erythritol — — — — — — — — — 10 — Trehalose — — — — — —— — — — 10 Palatinit 10 5 10 20 30 60 — — — — — Remineralization 8521328 1468 1496 1548 1580 320 1024 958 842 862 value

[0050] From the above Table 3, it was found that palatinit has theparticularly excellent remineralizing ability, also in the evaluation ofExamples 1-6 and Comparative Examples 1-5.

EXPERIMENTAL EXAMPLE 3

[0051] Evaluation of the Remineralizing Ability 3

[0052] The remineralization enhancing effect of the oral composition towhich the zinc compound had been added was tested in vitro according toalmost the same manner as that described in Experimental Example 1.

[0053] Provided that, in the remineralization treatment, a solutioncontaining 3.0 mM calcium ion and 1.8 mM phosphate ion to which the testdentifrice (see Table 4) had been added so as to form a 4-fold slurrywas used, and the pH cycling procedure was taken in which the enamelblock was additionally immersed in the demineralization solution forthree hours per day. An evaluation period was set to be fourteen days.The results of the X-ray photograph were evaluated using the imageprocessor according to a similar manner to that described inExperimental Example 1. The results are shown in Table 4. TABLE 4Comparative Comparative Ingredients Example 7 Example 8 Example 9Example 10 Example 11 Example 12 Example 13 Example 6 Example 7 Silicicacid anhydride 20 20 20 20 20 20 20 20 20 Sodium 1.5 1.5 1.5 1.5 1.5 1.51.5 1.5 1.5 carboxymethyl cellulose Sorbitol 40 40 35 25 35 35 35 50 35Sodium lauryl sulfate 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Saccharinsodium 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Sodium fluoride — 0.2 0.2 0.20.2 0.2 0.2 — 0.2 Flavor 1 1 1 1 1 1 1 1 1 Xylitol — — — — — — — — 10Palatinit 10 10 10 20 10 10 10 — — Zinc oxide 1 — 1 — — 0.1 5 1 — Zincstearate — — — 1 — — — — — Zinc citrate — — — — 1 — — — —Remineralization value 102 513 542 516 630 530 721 10 354

[0054] From the above Table 4, in the evaluation of Examples 7-13 andComparative Examples 6-7, it was shown that the remineralization isenhanced by blending palatinit and a zinc compound.

EXPERIMENTAL EXAMPLE 4

[0055] Organoleptic Evaluation of the Astringency 1

[0056] The oral compositions of Examples 14-16 and Comparative Examples8-9 in Table 5 were prepared. Ten healthy persons used these oralcompositions according to the conventional manner, and the astringencyafter spout was organoleptically evaluated. The total points of tenhealthy persons are shown according to the following 3 grades-criteria:2: excellent; 1: good; 0: astringent.

[0057] The results are shown in FIG. 5. TABLE 5 Comparative ComparativeIngredients Example 14 Example 15 Example 16 Example 8 Example 9 Silicicacid 20 20 20 20 20 anhydride Sodium  1.5  1.5  1.5  1.5  1.5carboxymethyl cellulose Sorbitol 35 35 35 35 35 Sodium lauryl  1.5  1.5 1.5  1.5  1.5 sulfate Saccharin sodium  0.1  0.1  0.1  0.1  0.1 Sodiumfluoride  0.2*  0.2  0.2  0.2  0.2 Flavor  1  1  1  1  1 Zinc oxide 1  1— —  1 — Zinc oxide 2 —  1 — — — Zinc oxide 3 — —  1 —  1 Palatinit 1010 10 — — Total point 15 17 17  0  2

[0058] Zinc oxide 1: The average particle diameter is 0.5 μm and thespecific surface area is 8 m²/g.

[0059] Zinc oxide 2: The average particle diameter is 0.28 μm and thespecific surface area is 10 m²/g.

[0060] Zinc oxide 3: The average particle diameter is 0.04 μm and thespecific surface area is 25 m²/g.

[0061] From the above Table 5, it was found that the astringency can beimproved by decreasing the average particle diameter of zinc oxide orincreasing the specific surface area thereof, and can be furtherimproved by combing with palatinit.

EXPERIMENTAL EXAMPLE 5

[0062] Organoleptic Evaluation of the Astringency 2

[0063] The oral compositions of Examples 17-18 and Comparative Example10 having the varied pH values were prepared, and evaluated according toa similar manner to that described above.

[0064] The results are shown in Table 6. TABLE 6 Comparative IngredientsExample 17 Example 18 Example 10 Silicic acid anhydride 20 20 20 Sodiumcarboxymethyl 1.5 1.5 1.5 cellulose Sorbitol 35 35 35 Sodium laurylsulfate 1.5 1.5 1.5 Saccharin sodium 0.1 0.1 0.1 Sodium fluoride 0.2 0.20.2 Flavor 1 1 1 Zinc oxide 2* 1 1 1 Palatinit 10 10 10 Disodium 0.1 0.10.1 hydrogenphosphate Sodium 0.25 0.2 0.3 dihydrogenphosphate pH 6.0 7.05.0 Total point 16 17 10

[0065] From the above Table 6, it was shown that the astringency can beimproved by adjusting pH of the oral composition to 6.0 or higher.

EXAMPLE 19

[0066] Toothpaste

[0067] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 10.0Sodium fluoride 0.2 (The concentration in terms of fluoride ion is 905ppm) Silicic acid anhydride 16.0 Sodium carboxymethyl cellulose 1.3Sodium lauryl sulfate 1.0 Titanium dioxide 0.4 Paraoxybenzoic acid ester0.1 Citric acid 0.1 Trisodium citrate 0.3 Saccharin sodium 0.1 Flavor0.6 Sorbitol 50.0 Purified water balance Total 100.0

EXAMPLE 20

[0068] Toothpaste

[0069] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 30.0Silicic acid anhydride 20.0 Sodium carboxymethyl cellulose 1.2 Sodiumlauryl sulfate 1.2 Titanium dioxide 0.3 Hydrochloric acid 0.5 Saccharinsodium 0.13 Sorbitol 10.0 Flavor 1.0 Purified water balance Total 100.0

EXAMPLE 21

[0070] Toothpaste

[0071] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 50.0Sodium fluoride 0.2 (The concentration in terms of fluoride ion is 905ppm) Silicic acid anhydride 16.0 Carrageenan 1.3 Sodium lauryl sulfate3.5 Titanium dioxide 0.4 Paraben 0.1 Xylitol 10.0 Flavor 0.7 Glycerol5.0 Purified water balance Total 100.0

EXAMPLE 22

[0072] Toothpaste

[0073] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 15.0Sodium monofluorophosphate 0.76 (The concentration in terms of fluorideion is 950 ppm) Calcium carbonate 16.0 Sodium carboxymethyl cellulose1.3 Sodium lauroylsarcosinate 2.0 Polyoxyethylene hydrogenated castoroil 1.0 Titanium dioxide 0.4 Paraoxybenzoic acid ester 0.1 Malic acid0.2 Stevia extract 0.1 Flavor 0.7 Sorbitol 40.0 Polyethylene glycol 5.0Purified water balance Total 100.0

EXAMPLE 23

[0074] Toothpaste

[0075] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 5.0Sodium fluoride 0.21 (The concentration in terms of fluoride ion is 950ppm) Triclosan 0.5 Silicic acid anhydride 16.0 Sodium polyacrylate 2.0Sodium lauryl sulfate 1.0 Pluronic 1.0 Titanium dioxide 0.4Paraoxybenzoic acid ester 0.1 Xylitol 10.0 Flavor 0.7 Sorbitol 50.0Purified water balance Total 100.0

EXAMPLE 24

[0076] Mouthwash

[0077] A mouthwash was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 10.0Sodium fluoride 0.05 (The concentration in terms of fluoride ion is 225ppm) Sodium lauryl sulfate 0.5 Polyoxyethylene hydrogenated castor oil1.0 Sodium dihydrogenphosphate 0.1 Disodium hydrogenphophate 0.1Saccharin sodium 0.1 Flavor 0.7 Ethanol 10.0 Glycerol 10.0 Purifiedwater balance Total 100.0

EXAMPLE 25

[0078] Mouthwash

[0079] A mouthwash was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 30.0Polyoxyethylene hydrogenated castor oil 1.0 Sodium citrate 0.2 Citricacid anhydride 0.2 Flavor 0.8 Glycerol 10.0 Purified water balance Total100.0

EXAMPLE 26

[0080] Mouthwash

[0081] A mouthwash was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 10.0Sodium fluoride 0.05 (The concentration in terms of fluoride ion is 225ppm) Sodium lauryl sulfate 0.2 Polyoxyethylene (2)-synthetic C₁₂, C₁₄alkyl- sodium sulfosuccinate 0.2 Malic acid 0.3 Flavor 0.7 Glycerol 10.0Xylitol 5.0 Purified water balance Total 100.0

EXAMPLE 27

[0082] Gel Dentifrice

[0083] A gel dentifrice was prepared by the following formulationaccording to the conventional procedures. Ingredients Amounts %Palatinit 10.0 Hydroxyethyl cellulose 3.0 Sodium fluoride 1.0 (Theconcentration in terms of fluoride ion is 4,500 ppm) Phosphoric acid 3.0Saccharin sodium 0.5 Flavor 0.8 Glycerol 20.0 Purified water balanceTotal 100.0

EXAMPLE 28

[0084] Non Aerosol-type Foam Dentifrice

[0085] A non aerosol-type foam dentifrice was prepared by the followingformulation according to the conventional procedures. IngredientsAmounts % Palatinit 5.0 Sodium fluoride 1.0 (The concentration in termsof fluoride ion is 4,500 ppm) Phosphoric acid 3.0 Tripotassium phosphatetrihydrate 1.5 Sodium lauryl sulfate 1.0 Pluronic 7.0 Coconut oil fattyacid diethanolamide 0.5 Saccharin sodium 0.8 Flavor 0.7 Ethanol 5.0Purified water balance Total 100.0

EXAMPLE 29

[0086] Oral Gel

[0087] An oral gel was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 20.0Carboxymethyl cellulose 0.2 Glycerol 40.0 Grape seed extract 1.0α-tocopherol 0.05 Purified water balance Total 100.0

EXAMPLE 30

[0088] Toothpaste

[0089] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 10.0Sodium fluoride 0.21 (The concentration in terms of fluoride ion is 950ppm) Silicic acid anhydride 21.0 Sodium carboxymethyl cellulose 1.1Sodium lauryl sulfate 0.5 Sodium lauroylsarcosinate 0.1 Titanium dioxide0.3 Fine particle zinc oxide 1.0 (The average particle diameter is 0.3μm: the specific surface area is 10 m²/g) Paraoxybenzoic acid ester 0.1Saccharin sodium 0.1 Flavor 0.7 Xylitol 1.0 Sorbitol 38.0 Hydrochloricacid (2N) 1.0 Purified water balance Total 100.0 pH 6.5

EXAMPLE 31

[0090] Toothpaste

[0091] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 50.0Zinc stearate 1.0 Sodium fluoride 0.21 (The concentration in terms offluoride ion is 950 ppm) Silicic acid anhydride 16.0 Carrageenan 1.3Sodium lauryl sulfate 3.5 Titanium dioxide 0.4 Paraben 0.1 Xylitol 10.0Flavor 0.7 Glycerol 5.0 Purified water balance Total 100.0 pH 7.0

EXAMPLE 32

[0092] Toothpaste

[0093] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 15.0Zinc citrate 0.5 Sodium monofluorophosphate 0.75 (The concentration interms of fluoride ion is 950 ppm) Calcium carbonate 16.0 Sodiumcarboxymethyl cellulose 1.3 Sodium lauroylsarcosinate 2.0Polyoxyethylene hydrogenated castor oil 1.0 Titanium dioxide 0.4Paraoxybenzoic acid ester 0.1 Malic acid 0.2 Stevia extract 0.1 Flavor0.7 Sorbitol 40.0 Polyethylene glycol 5.0 Purified water balance Total100.0 pH 7.5

EXAMPLE 33

[0094] Toothpaste

[0095] A toothpaste was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 5.0 Fineparticle zinc oxide 1.5 (The average particle diameter is 0.3 μm: thespecific surface area is 10 m²/g.) Sodium fluoride 0.21 (Theconcentration in terms of fluoride ion is 950 ppm) Triclosan 0.5 Silicicacid anhydride 16.0 Sodium polyacrylate 2.0 Sodium lauryl sulfate 1.0Pluronic 1.0 Titanium dioxide 0.4 Paraoxybenzoic acid ester 0.1 Xylitol10.0 Flavor 0.7 Sorbitol 50.0 Hydrochloric acid (1N) 1.5 Purified waterbalance Total 100.0 pH 6.8

EXAMPLE 34

[0096] Mouthwash

[0097] A mouthwash was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 10.0Zinc citrate 0.1 Sodium fluoride 0.05 (The concentration in terms offluoride ion is 225 ppm) Sodium lauryl sulfate 0.5 Polyoxyethylenehydrogenated castor oil 1.0 Sodium dihydrogenphosphate 0.1 Disodiumhydrogenphophate 0.1 Saccharin sodium 0.1 Flavor 0.7 Ethanol 10.0Glycerol 10.0 Purified water balance Total 100.0 pH 6.0

EXAMPLE 35

[0098] Mouthwash

[0099] A mouthwash was prepared by the following formulation accordingto the conventional procedures. Ingredients Amounts % Palatinit 10.0Fine particle zinc oxide 0.1 (The average particle diameter is 0.3 μm:the specific surface area is 10 m²/g) Sodium fluoride 0.05 (Theconcentration in terms of fluoride ion is 225 ppm) Sodium lauryl sulfate0.2 Polyoxyethylene (2)-synthetic C₁₂, C₁₄ alkyl- 0.2 sodiumsulfosuccinate Malic acid 0.3 Flavor 0.7 Glycerol 10.0 Xylitol 5.0Purified water balance Total 100.0 pH 7.5

EXAMPLE 36

[0100] Gel Dentifrice

[0101] A gel dentifrice was prepared by the following formulationaccording to the conventional procedures. Ingredients Amounts %Palatinit 10.0 Fine particle zinc oxide 0.1 (The average particlediameter is 0.3 μm: the specific surface area is 10 m²/g) Sodiumfluoride 1.0 (The concentration in terms of fluoride ion is 4,500 ppm)Phosphoric acid 3.0 Saccharin sodium 0.5 Flavor 0.8 Glycerol 20.0Hydrochloric acid (2N) 1.0 Purified water balance Total 100.0 pH 6.9

EXAMPLE 37

[0102] Oral Gel Ingredients Amounts % Palatinit 20.0 Carboxymethylcellulose 0.2 Fine particle zinc oxide 0.1 (The average particlediameter is 0.3 μm: the specific surface area is 10 m²/g) Glycerol 40.0Grape seed extract 1.0 α-tocopherol 0.05 Purified water balance Total100.0 pH 8.5

INDUSTRIAL APPLICABILITY

[0103] The present invention relates to an oral composition, which hasthe high safety, comprising either palatinit alone or in combinationwith fluorine compound, as well as an oral composition comprisingpalatinit in combination with zinc compound, which improves a badfeeling for use due to the zinc compound, and, by the inclusion of saidingredient, the present invention can provide an oral composition whichcan enhance remineralization.

1. An oral composition comprising palatinit.
 2. The oral compositionaccording to claim 1, further comprising a remineralization enhancingingredient.
 3. The oral composition of claim 2, comprising a fluorinecompound as a remineralization enhancing ingredient.
 4. The oralcomposition according to claim 3, wherein said fluorine compound issodium fluoride.
 5. The oral composition according to claim 2,comprising a zinc compound as a remineralization enhancing ingredient.6. The oral composition according to claim 5, wherein said zinc compoundis a water-slightly soluble zinc compound.
 7. The oral compositionaccording to claim 6, wherein said water-slightly soluble zinc compoundis one or more selected from the group consisting of zinc oxide, zinccitrate and zinc stearate.
 8. The oral composition according to claim 6,wherein said water-slightly soluble zinc compound is a powder having theaverage particle diameter of not greater than 0.3 μm and the specificsurface area of greater than 10 m²/g.
 9. The oral composition accordingto claim 5, which is pH of 6.0-8.5.
 10. The oral composition accordingto claim 9, wherein hydrochloric acid is used as a pH adjusting agent.11. The oral composition according to claim 5, further comprising afluorine compound.
 12. The oral composition of claim 11, wherein saidfluorine compound is sodium fluoride.